About Mina Safain, MD

Special Interests

Minimally invasive spine surgery, pain reduction techniques after spinal surgery, imaging techniques in vascular neurosurgery


Yale University School of Medicine

Additional Language(s)



Tufts Medical Center


Tufts Medical Center


Brigham and Women’s Hospital

Board Certification



Mina Safain, MD grew up in Holliston, MA completing his undergraduate education at the University of Massachusetts-Amherst and then attending medical school at the Yale University School of Medicine. He returned to Boston for neurosurgical residency at Tufts Medical Center serving as Chief Resident his final year and completed an additional fellowship in Pituitary and Neuroendoscopic surgery at Brigham and Women’s Hospital under Dr. Edward Laws. He is board certified in Neurosurgery.

Dr. Safain currently treats patients at both MelroseWakefield Hospital and Tufts Medical Center. He has interests in all diseases affecting the brain, spine, and peripheral nervous systems. Dr. Safain has specific interest and expertise in minimally invasive treatments for brain tumors including neuroendoscopy, as well as minimal access procedures for degenerative, infectious, and oncologic spine disorders. This includes treatment of pituitary tumors, meningiomas, spinal stenosis, disc herniation, and spondylolisthesis. He is also quite interested in all general neurosurgical diseases including traumatic brain and spine injury, cerebrovascular disorders, and intracerebral hemorrhage.

In his spare time, Dr. Safain enjoys outdoor music, cooking and being outside with his family.

Honors and Awards

June 2014, William Scoville Award for Best Clinical Paper at the New England Neurosurgical Society Annual Meeting
May 2013, Excellence in Teaching Award, Tufts University School of Medicine
May 2005, 21st Century Leader Award, University of Massachusetts Amherst
May 2005, Summa Cum Laude, Biochemistry and Molecular Biology, University of Massachusetts Amherst
April 2005, Natural Sciences and Mathematics Outstanding Undergraduate Award, University of Massachusetts Amherst

Publications + National Presentations

1. Safain MG, Roguski M, Heller RS, Malek AM. Flow Diverter Therapy with the Pipeline Embolization Device is Associated with an Elevated Rate of Delayed Fluid-Attenuated Inversion Recovery Lesions. Stroke. 2016. Mar; 47(3):789-97.

2. Safain MG, Burke SM, Riesenburger RI, Zerris V, Hwang SW. The effect of spinal osteotomies on spinal cord tension and dural buckling: a cadaveric study. J Neurosurg Spine. 2015 Jull 23(1):120-7.

3. Safain MG, Rahal JP, Patel S, Lauric A, Feldmann E, Malek AM. Superior performance of cone-beam CT angiography in characterization of intracranial atherosclerosis. J. Neurosurg. 2014 Aug; 121(2):441-9.

4. Safain M, Roguski M, Antoniou A, Schirmer CS, Malek AM, Riesenburger R. A single center’s experience with the bedside subdural evacuating port system: a useful alternative to traditional methods for chronic subdural hematoma evacuation. J. Neurosurg. 2013 Mar; 118(3):694-700

5. Safain MG, Rahal JP, Raval A, Rivard MJ, Mignano J, Wu J, Malek AM. Utilization of Cone-Beam Computed Tomographic Angiography in Planning for Gamma Knife Radiosurgery of Arteriovenous Malformations: A Case Series and Early Report. Neurosurgery 2014. Jun; 74(6):682-95.

6. Safain MG, Talan J, Malek AM, Hwang SW. Spontaneous atraumatic vertebral artery occlusion due to physiological cervical extension. J. Neurosurg Spine. 2014; Mar; 20(3): 278-282.

7. Safain MG, Dent WC, Heilman CB. An endoscopic assisted retrosigmoid approach to the cerebello-pontine angle for resection of an epidermoid cyst. Neurosurg Focus. 2014 Jan;36(1 Suppl):1.

8. Safain M, Shepard M, Rahal J, Kryzanski J, Hwang S, Roguski M, Riesenburger RI. Successful management of an acute subdural hematoma in a patient dependent on continuous treprostinil infusion therapy. J. Neurosurg. 2013 Apr 118(4):753-6.

9. Safain MG, Roguski M, Kryzanski JT, Weller SJ. A review of the combined medical and surgical management in patients with herpes simplex encephalitis. Clin Neurol Neurosurg. 2015 Jan;128:10-6.

10. Kelly JC, Safain MG, Roguski M, Edlow AG, Malek AM. Postpartum Internal Carotid and Vertebral Arterial Dissections. Obstet Gynecol. 2014 Apr; 123 (4), 848-856.

Contact Info

  • Office Locations:
  • Melrose
    MelroseWakefield Hospital, 585 Lebanon Street, Melrose, MA 02176
    Suite 401
  • 781-979-3070
  • 781-979-3421

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