Drug Rashes

What are drug rashes?

Most rashes that are caused by an allergic reaction to a drug appear as hives or are very itchy. Hives are raised pink spots with white centers. Their size, shape, and location change frequently. Some less common rashes caused by drug allergies are widespread red patches or target-shaped rashes.

A rash caused by an allergic reaction appears on most of the body. A rash that affects just one part of the body is not caused by drugs.

Another kind of rash may occur when a child is taking amoxicillin or ampicillin. It is called a nonallergic amoxicillin rash. It consists of small pink spots, mainly on the chest, abdomen, and back. The rash is not caused by an allergic reaction to the medicine. A child who has such a rash can continue taking the medicine.

Rashes in children are more likely to be caused by a viral infection such as roseola, than by a medicine.

How can I take care of my child?

  • Stopping the medication

    If your child is diagnosed as being allergic to a medicine, he can never take any drugs in that drug category again. (For example, if he is allergic to one type of penicillin, he cannot take any of the penicillin drugs.) Hence, this is a critical decision. Unless your healthcare provider tells you otherwise, have your child examined before you stop a medicine. However, there are a few exceptions. Stop the drug if:

    • Your child is taking antiseizure or sulfa drugs.
    • The rash is severe.
    • You are certain your child has hives.
  • Replacing the antibiotic

    Anytime antibiotics are discontinued before a child has completed the full treatment, a doctor should see the child within 24 hours to determine whether he or she needs a new antibiotic. Without this precaution, many children will have flare-ups of partially treated infections.

When should I call my child’s healthcare provider?


  • Your child has hives or is very itchy.
  • The rash is severe.
  • The rash is purple or blood-colored spots or dots.
  • Your child is acting very sick.

Call within 24 hours about:

  • All children with mild widespread rashes that occur while they are taking a medicine.
Written by Barton D. Schmitt, MD, author of “My Child Is Sick,” American Academy of Pediatrics Books.
Pediatric Advisor 2015.1 published by RelayHealth.
Last modified: 2009-06-18
Last reviewed: 2014-06-10
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
Copyright ©1986-2015 Barton D. Schmitt, MD. All rights reserved.

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