Iron overload disease is a condition that causes iron to build up in your body. This disease is also called hemochromatosis.
The buildup of iron can damage or destroy organs. The buildup of iron in the body can cause:
Scarring of the liver, called cirrhosis, which may cause your liver to stop working
An irregular heartbeat or weak heart muscle
Diabetes (caused by damage to the pancreas)
If the disease is found early, it can be treated and the damage can be prevented.
What is the cause?
The most common causes of iron overload disease are:
Having frequent blood transfusions to treat certain kinds of anemia
Taking too many iron supplements
Inheriting a defect in the genes that control how much iron your body absorbs from food. Genes are in each cell of your body. They contain the information that tells your body how to develop and work. Changes in the genes can be passed from parents to children. If you inherited the gene from both of your parents, it is likely you will have the disease. If you inherited the faulty gene from just 1 of your parents, usually you will not have the disease, but you can pass the gene on to your children.
Iron overload disease is more common in people of English, French, Swedish, or Portuguese descent.
What are the symptoms?
You may not have any symptoms for years. Symptoms usually start in middle age. They include:
Feeling tired (the most common symptom)
Arthritis (joint pains, especially in the fingers, hips, and knees)
A change in your skin color to gray or brown
Fast or irregular heartbeat
Problems having or keeping an erection
Irregular or no menstrual periods
Trouble getting pregnant
Symptoms of diabetes, such as being very thirsty and urinating a lot
Symptoms of liver problems, such as nausea, loss of appetite, swelling of the belly, stomach pain, and vomiting of blood
Men may start having symptoms between 30 and 50 years of age. Women often donâ€™t start having symptoms until menopause. Before menopause women are protected somewhat from the disease because they lose iron when they have periods and during childbirth.
How is it diagnosed?
Your healthcare provider will ask about your symptoms and medical history and examine you. Tests may include:
A liver biopsy may be taken to help make a diagnosis. A biopsy is the removal of a small sample of tissue for testing.
How is it treated?
The treatment is to remove excess iron from your body by removing blood. Your blood is taken the same way it is when you donate blood. When your level of iron is high, you may need to have a pint of blood removed once or twice a week for several months. Your iron levels will be checked with blood tests to know how much blood needs to be taken. When your iron levels are back to normal, you will probably need to repeat the treatment every 2 to 4 months to keep normal levels.
If you have the gene that causes your body to absorb too much iron from the food you eat, your provider may suggest changes to your diet. You may also need to avoid iron and vitamin C supplements, both of which are in many multiple vitamins. Vitamin C helps your body absorb more iron.
You may need treatment for problems caused by damage to your organs, such as:
To help prevent liver damage, avoid drinking alcohol. You should also avoid taking medicines that can damage the liver more (for example, acetaminophen).
How can I take care of myself?
Follow your healthcare provider’s instructions for taking medicine.
Eat a healthy diet according to your providerâ€™s instructions.
Donâ€™t drink alcohol.
Ask your provider:
How and when you will hear your test results
How long it will take to recover
If there are activities you should avoid and when you can return to your normal activities
How to take care of yourself at home
What symptoms or problems you should watch for and what to do if you have them
Make sure you know when you should come back for a checkup.
How can I help prevent iron overload disease?
If you have a family history of iron overload disease, you should have tests to see if you have the disease or if your iron levels are getting too high. With early diagnosis and treatment, organ damage caused by iron overload disease can be prevented.
Developed by RelayHealth.
Adult Advisor 2015.1 published by RelayHealth. Last modified: 2014-05-27 Last reviewed: 2014-07-10
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
Iron Overload Disease (Hemochromatosis): References
National Digestive Diseases Information Clearinghouse (NDDIC). Hemochromatosis.
US Department of Health and Human Services, National Institutes of Health, National Digestive Diseases Information Clearinghouse. March, 2014. Accessed 6/2014 from